Brain glucose metabolism: integration of energetics with function
GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
including ATP production, oxidative stress management, and synthesis of neurotransmitters …
Physiology of astroglia
A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …
Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte–neuron lactate shuttle in brain
GA Dienel - Journal of Neuroscience Research, 2017 - Wiley Online Library
Glutamate‐stimulated aerobic glycolysis in astrocytes coupled with lactate shuttling to
neurons where it can be oxidized was proposed as a mechanism to couple excitatory …
neurons where it can be oxidized was proposed as a mechanism to couple excitatory …
Aerobic glycolysis during brain activation: adrenergic regulation and influence of norepinephrine on astrocytic metabolism
GA Dienel, NF Cruz - Journal of neurochemistry, 2016 - Wiley Online Library
Aerobic glycolysis occurs during brain activation and is characterized by preferential up‐
regulation of glucose utilization compared with oxygen consumption even though oxygen …
regulation of glucose utilization compared with oxygen consumption even though oxygen …
Physiology of astroglia
Astrocytes are principal cells responsible for maintaining the brain homeostasis.
Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and …
Additionally, these glial cells are also involved in homocellular (astrocyte-astrocyte) and …
Glial chloride homeostasis under transient ischemic stress
M Engels, M Kalia, S Rahmati, L Petersilie… - Frontiers in cellular …, 2021 - frontiersin.org
High water permeabilities permit rapid adjustments of glial volume upon changes in external
and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–] …
and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–] …
Astrocytes: the housekeepers and guardians of the CNS
Astroglia are a diverse group of cells in the central nervous system. They are of the
ectodermal, neuroepithelial origin and vary in morphology and function, yet, they can be …
ectodermal, neuroepithelial origin and vary in morphology and function, yet, they can be …
Exacerbation of epilepsy by astrocyte alkalization and gap junction uncoupling
M Onodera, J Meyer, K Furukawa… - Journal of …, 2021 - Soc Neuroscience
Seizures invite seizures. At the initial stage of epilepsy, seizures intensify with each episode;
however, the mechanisms underlying this exacerbation remain to be solved. Astrocytes …
however, the mechanisms underlying this exacerbation remain to be solved. Astrocytes …
Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders
Nutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified
medium-chain triglycerides, is an established treatment for pharmaceutical resistant …
medium-chain triglycerides, is an established treatment for pharmaceutical resistant …
Role of glycogenolysis in memory and learning: regulation by noradrenaline, serotonin and ATP
ME Gibbs - Frontiers in integrative neuroscience, 2016 - frontiersin.org
This paper reviews the role played by glycogen breakdown (glycogenolysis) and glycogen
re-synthesis in memory processing in two different chick brain regions,(1) the hippocampus …
re-synthesis in memory processing in two different chick brain regions,(1) the hippocampus …