HER3, a member of the EGFR family of receptor tyrosine kinases coded by the ERBB3 gene,
plays an important role in cancer, despite its lack of intrinsic kinase activity. As with genes …

Each member of the epidermal growth factor receptor (EGFR) family plays a key role in
normal development, homeostasis, and a variety of pathophysiological conditions, most …

Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer characterized by complex
metabolic adaptations that promote survival in a severely hypoxic and nutrient-limited tumor …

Bispecific antibodies combine two different antigen-binding sites in a single molecule,
enabling more specific targeting, novel mechanisms of action, and higher clinical efficacies …

PET imaging with radiolabeled drugs provides information on tumor uptake and dose-
dependent target interaction to support selection of an optimal dose for future efficacy …

The human epidermal growth factor receptor (HER) family of receptor tyrosine kinases
(RTKs) are among the first layer of molecules that receive, interpret, and transduce signals …

Despite impressive clinical benefit obtained with anti‐HER2‐targeted therapies, in advances
stages, especially in the metastatic setting, HER2‐positive tumors remain incurable …

Purpose: Because of emergence of resistance to osimertinib, a third-generation EGFR
tyrosine kinase inhibitor (TKI), no targeted treatments are available for patients with lung …

Epidermal growth factor receptor (EGFR) mutations identify patients with lung cancer who
derive benefit from kinase inhibitors. However, most patients eventually develop resistance …

ABSTRACT Introduction The importance of ErbB3 receptor tyrosine kinase in cancer
progression, primary and acquired drug resistance, has become steadily evident since its …