The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

Inherent susceptibility of peptides to enzymatic degradation in the gastrointestinal tract is a
key bottleneck in oral peptide drug development. Here, we present a systematic analysis of …

The development of oral dosage forms that allows absorption of therapeutic peptides to the
systemic circulation is one of the greatest challenges for the pharmaceutical industry …

Targeting protein-protein interactions (PPIs) has been recently recognized as an emerging
therapeutic approach for several diseases. Up today, more than half a million PPI …

OBJECTIVES: Two identical, phase 3, randomized, double-blind, placebo-controlled trials
evaluated the efficacy and safety of plecanatide in patients with irritable bowel syndrome …

Progesterone and progesterone receptors (PRs) are essential for the development and
cyclical regulation of hormone-responsive tissues including the breast and reproductive …

Optoacoustic (photoacoustic) imaging offers unique opportunities for visualizing biological
function in vivo by achieving high-resolution images of optical contrast much deeper than …

Objectives: This study assessed the efficacy and safety of plecanatide, a guanylate cyclase-
C (GC-C) agonist and the first uroguanylin analog approved for the treatment of chronic …

Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …