On-target resistance to the mutant-selective EGFR inhibitor osimertinib can develop in an allele-specific manner dependent on the original EGFR-activating mutation

BP Brown, YK Zhang, D Westover, Y Yan, H Qiao… - Clinical Cancer …, 2019 - AACR
Purpose: The third-generation EGFR inhibitor, osimertinib, is the first mutant-selective
inhibitor that has received regulatory approval for the treatment of patients with EGFR …

[HTML][HTML] Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey

JP Gregg, T Li, KY Yoneda - Translational lung cancer research, 2019 - ncbi.nlm.nih.gov
Molecular testing identifies patients with advanced non-small cell lung cancer (NSCLC) who
may benefit from targeted therapy or immunotherapy (ie, immune checkpoint inhibitor …

Novel targets, novel treatments: the changing landscape of non-small cell lung cancer

D de Jong, JP Das, H Ma, J Pailey Valiplackal… - Cancers, 2023 - mdpi.com
Simple Summary Non-small cell lung cancer treatment has undergone a revolution in the
past decade owing to the discovery of mutations that drive carcinogenesis and the …

Imaging-based prediction of molecular therapy targets in NSCLC by radiogenomics and AI approaches: a systematic review

G Ninatti, M Kirienko, E Neri, M Sollini, A Chiti - Diagnostics, 2020 - mdpi.com
The objective of this systematic review was to analyze the current state of the art of imaging-
derived biomarkers predictive of genetic alterations and immunotherapy targets in lung …

Liquid biopsies in lung cancer

M Kemper, C Krekeler, K Menck, G Lenz, G Evers… - Cancers, 2023 - mdpi.com
Simple Summary Liquid biopsy has recently been introduced as a novel method in cancer
diagnostics. It is less invasive for patients than conventional tissue biopsies, as the assay …

Atezolizumab in combination with bevacizumab, paclitaxel and carboplatin for the first-line treatment of patients with metastatic non-squamous non-small cell lung …

M Reck, G Shankar, A Lee, S Coleman… - Expert review of …, 2020 - Taylor & Francis
Introduction: Cancer immunotherapy has revolutionized the treatment of patients with
advanced or metastatic non-small cell lung cancer (NSCLC). However, specific patient …

Exosomes in lung cancer diagnosis and treatment. From the translating research into future clinical practice

C Masaoutis, C Mihailidou, G Tsourouflis, S Theocharis - Biochimie, 2018 - Elsevier
Lung cancer is one of the main causes of cancer-related death worldwide. Despite
advances in lung cancer pathophysiology, diagnosis and prognosis, a better understanding …

[图书][B] Holland-Frei cancer medicine

RC Bast Jr, CM Croce, WN Hait, WK Hong, DW Kufe… - 2017 - books.google.com
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current
knowledge of cancer science and clinical oncology practice. This all-new edition is the …

[HTML][HTML] Real-world effectiveness and safety of nivolumab in patients with non-small cell lung cancer: A multicenter retrospective observational study in Japan

R Morita, K Okishio, J Shimizu, H Saito, H Sakai… - Lung Cancer, 2020 - Elsevier
Objectives To describe the treatment patterns and determine the effectiveness and safety of
nivolumab treatment for non-small cell lung cancer (NSCLC) in real-world setting in Japan …

Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan‐cancer analysis

H Liu, B Zhang, Z Sun - Cancer communications, 2020 - Wiley Online Library
Background Human epidermal growth factor receptor (EGFR) is an oncogenic gene and one
of top targets of precision therapy in lung cancer with EGFR mutations. Although there are …