MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

MicroRNAs (miRNA) are a group of small non-coding RNAs that regulate gene expression
at the RNA level. MicroRNAs have positive regulatory effects on protein translation …

Abstract Methyltransferase-like 3 (METTL3) is involved in RNA metabolism through N6-
methyladenosine (m 6 A) modification. However, whether METTL3 participates in the …

Dysregulation of microRNAs (miRNAs) is involved in the initiation and progression of
several human cancers, including breast cancer (BC), as strong evidence has been found …

Cancer has long been viewed as a disease of normal development gone awry. Cancer stem-
like cells (CSCs), also termed as tumor-initiating cells (TICs), are increasingly recognized as …

The endothelium is capable of remarkable plasticity. In the embryo, primitive endothelial
cells differentiate to acquire arterial, venous or lymphatic fates. Certain endothelial cells also …

Abundantly expressed in fetal tissues and adult muscle, the developmentally regulated H19
long noncoding RNA (lncRNA) has been implicated in human genetic disorders and cancer …

Abnormal regulation and expression of microRNAs (miRNAs) has been documented in
various diseases including cancer. The miRNA let-7 (MIRLET7) family controls …

Summary Lin28A and Lin28B selectively block the expression of let-7 microRNAs and
function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase …