Urea and thiourea represent privileged structures in medicinal chemistry. Indeed, these
moieties constitute a common framework of a variety of drugs and bioactive compounds …

Owing to their non‐toxic, stable, inexpensive properties, carboxylic acids are considered as
environmentally benign alternatives as coupling partners in various organic transformations …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

Herein, we describe the development of a copper‐catalyzed C (sp3)‐amination of
proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the …

The catalytic union of amides, sulfonamides, anilines, imines, or N-heterocycles with a broad
spectrum of electronically and sterically diverse alkyl bromides has been achieved via a …

Parallel library synthesis is an important tool for drug discovery because it enables the
synthesis of closely related analogues in parallel via robust and general synthetic …

Recent years have witnessed important progress in synthetic strategies exploiting the
reactivity of carbocations via photochemical or electrochemical methods. Yet, most of the …

A nickel-catalyzed reductive cross-coupling of cyclopropylamine NHP esters with (hetero)
aryl halides is reported. This efficient protocol provides direct access to 1 …

Decarboxylative Csp3–N coupling reactions have been developed through electrochemical
oxidation of amino acids. The reaction proceeds via anodic oxidative decarboxylation of …

Direct synthetic routes to amidines are desired, as they are widely present in many
biologically active compounds and organometallic complexes. N-Acyl amidines in particular …