Acute lymphoblastic leukemia (ALL) in children and adolescents can involve the testes at
diagnosis or upon relapse. The testes were long considered pharmacologic sanctuary sites …

Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …

Background Vincristine plus dexamethasone pulses are generally used throughout
maintenance treatment for childhood acute lymphoblastic leukaemia. However, previous …

Few studies have described chimeric antigen receptor (CAR) T-cell therapy for patients with
B-cell acute lymphoblastic leukemia (B-ALL) with central nervous system leukemia (CNSL) …

Minimal residual disease that persists after chemotherapy is the most valuable prognostic
marker for haematological malignancies and solid cancers. Unfortunately, our …

The central nervous system (CNS) is the most important site of extramedullary disease in
adults with acute lymphoblastic leukemia (ALL). Although CNS disease is identified only in a …

Background A lower baseline bone marrow blast percentage (bBMB%) is associated with
better outcomes in patients with B‐cell acute lymphoblastic leukemia (B‐ALL) receiving …

To determine the prognostic significance of central nervous system (CNS) leukemic
involvement in newly diagnosed T-cell acute lymphoblastic leukemia (T-ALL), outcomes on …

Introduction Over the years, the Hispanic population living in the United States has
consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, high …

The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally
improved with risk-directed chemotherapy but therapy responses remain heterogeneous …