Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle
known as the circadian rhythm. Metabolic homeostasis is regulated by the circadian rhythm …

Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Alzheimer's disease (AD) is the most common type of dementia, and no disease-modifying
treatments are available to halt or slow its progression. Amyloid-beta (Aβ) is suggested to …

Sirtuins are evolutionarily conserved proteins that use nicotinamide adenine dinucleotide
(NAD+) as a co-substrate in their enzymatic reactions. There are seven proteins (SIRT1-7) in …

Modulation of basic biochemical and physiological processes by the circadian timing system
is now recognized as a fundamental feature of all mammalian organ systems. Within the …

Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer's
disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms …

Neurodegeneration in the central nervous system (CNS) is a defining feature of organismal
aging that is influenced by peripheral tissues. Clinical observations indicate that skeletal …

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …

A majority of patients with Alzheimer's disease (AD) experience some form of sleep
disruption, including nocturnal sleep fragmentation, increased daytime napping, decreased …