Beyond the average patient: how neuroimaging models can address heterogeneity in dementia
Dementia is a highly heterogeneous condition, with pronounced individual differences in
age of onset, clinical presentation, progression rates and neuropathological hallmarks, even …
age of onset, clinical presentation, progression rates and neuropathological hallmarks, even …
[HTML][HTML] Brain charts for the human lifespan
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …
and clinical studies of the human brain. However, no reference standards currently exist to …
Functional connectome–based predictive modeling in autism
Autism is a heterogeneous neurodevelopmental condition, and functional magnetic
resonance imaging–based studies have helped advance our understanding of its effects on …
resonance imaging–based studies have helped advance our understanding of its effects on …
Charting brain growth and aging at high spatial precision
Defining reference models for population variation, and the ability to study individual
deviations is essential for understanding inter-individual variability and its relation to the …
deviations is essential for understanding inter-individual variability and its relation to the …
[HTML][HTML] The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to …
P Sen, E Sherwin, K Sandhu, TFS Bastiaanssen… - Brain, behavior, and …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits
in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms …
in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms …
[HTML][HTML] Differences in regional brain structure in toddlers with autism are related to future language outcomes
Abstract Language and social symptoms improve with age in some autistic toddlers, but not
in others, and such outcome differences are not clearly predictable from clinical scores …
in others, and such outcome differences are not clearly predictable from clinical scores …
Whole brain white matter tract deviation and idiosyncrasy from normative development in autism and ADHD and unaffected siblings link with dimensions of …
Objective: The heterogeneity of autism spectrum disorder (ASD) and attention deficit
hyperactivity disorder (ADHD) preclude definitive identification of neurobiomarkers and …
hyperactivity disorder (ADHD) preclude definitive identification of neurobiomarkers and …
Interindividual differences in cortical thickness and their genomic underpinnings in autism spectrum disorder
C Ecker, CM Pretzsch, A Bletsch… - American Journal of …, 2022 - Am Psychiatric Assoc
Objective: Autism spectrum disorder (ASD) is accompanied by highly individualized
neuroanatomical deviations that potentially map onto distinct genotypes and clinical …
neuroanatomical deviations that potentially map onto distinct genotypes and clinical …
[HTML][HTML] Fractionating autism based on neuroanatomical normative modeling
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological,
and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism …
and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism …
Mapping the heterogeneous brain structural phenotype of autism spectrum disorder using the normative model
Background Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder
characterized by substantial clinical and biological heterogeneity. Quantitative and …
characterized by substantial clinical and biological heterogeneity. Quantitative and …