We have produced a surrogate erythrocyte ('hemosomes') by encapsulating human
hemoglobin in polymerized vesicles composed of diacetylenic phospholipids plus or minus …

Lipid bilayer membranes have been used to encapsulate hemoglobin and organic
phosphates, resulting in a synthetic red cell with oxygen-binding properties very similar to …

Abstract The combination solution of 7.5% NaCl/6% dextran 70 (HSD) administered IV gives
hemodynamic improvement in the treatment of hemorrhagic hypotension. Since earlier …

Over a 3-year-period 72 patients with upper digestive tract haemorrhage due to peptic ulcer
were transfused exclusively with isotonic sodium chloride and glucose solutions in equal …

Liposome-encapsulated hemoglobin (LEH) is being developed at the Naval Research
Laboratory as a universally transfusable oxygen-carrying blood replacement. A chemical …

The defibrinating agent ancrod has had limited clinical trial, but appears to give no
advantages over heparin. Intravenous infusion of dextran, a glucose polymer, has been …

By definition, plasma substitutes aim to replace a fluid which is colloidal in nature by virtue of
its content of different species of highly specialized proteins. In plasma, albumin is present in …

Encapsulation methods using high pressure extrusion and homogenization were developed
which produce hemoglobin-containing liposomes, approximately one micron or less in …

The synthetic colloids, dextran and hydroxyethyl starch, have only recently enjoyed
widespread use in critically ill veterinary patients. Plasma proteins normally provide colloid …

Fifty patients undergoing transurethral resection of the prostate were studied for evidence of
glycine absorption and haemodilution. Plasma glycine levels increased substantially in nine …