Lipid biomarkers in Alzheimer's disease
A Zarrouk, M Debbabi, M Bezine… - Current Alzheimer …, 2018 - ingentaconnect.com
Background: There are now significant evidences that lipid metabolism is affected in
numerous neurodegenerative diseases including Alzheimer's disease. These dysfunctions …
numerous neurodegenerative diseases including Alzheimer's disease. These dysfunctions …
[HTML][HTML] Cholesterol 24-hydroxylation by CYP46A1: benefits of modulation for brain diseases
AM Petrov, IA Pikuleva - Neurotherapeutics, 2019 - Elsevier
Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain
and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme …
and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
Color image encryption algorithm based on 5D memristive chaotic system and group scrambling
B Sun, C Zhang, Q Peng, B Du - Optik, 2023 - Elsevier
A 5D memristive chaotic system is proposed in this paper. The essential characteristics and
dynamic behavior of the obtained system are analyzed with the help of numerical simulation …
dynamic behavior of the obtained system are analyzed with the help of numerical simulation …
[HTML][HTML] CYP46A1 activation by low-dose efavirenz enhances brain cholesterol metabolism in subjects with early Alzheimer's disease
AJ Lerner, SE Arnold, E Maxfield, A Koenig… - Alzheimer's Research & …, 2022 - Springer
Background Efavirenz is an anti-HIV drug, and cytochrome P450 46A1 (CYP46A1) is a CNS-
specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have …
specific enzyme that metabolizes cholesterol to 24-hydroxycholesterol (24HC). We have …
[HTML][HTML] Cerebrospinal fluid neutral lipids predict progression from mild cognitive impairment to Alzheimer's disease
F Dakterzada, M Jové, R Huerto, A Carnes, J Sol… - GeroScience, 2024 - Springer
Genetic, metabolic, and clinical evidence links lipid dysregulation to an increased risk of
Alzheimer's disease (AD). However, the role of lipids in the pathophysiological processes of …
Alzheimer's disease (AD). However, the role of lipids in the pathophysiological processes of …
Alternative splicing in the cytochrome P450 superfamily expands protein diversity to augment gene function and redirect human drug metabolism
AJ Annalora, CB Marcus, PL Iversen - Drug Metabolism and Disposition, 2017 - ASPET
The human genome encodes 57 cytochrome P450 genes, whose enzyme products
metabolize hundreds of drugs, thousands of xenobiotics, and unknown numbers of …
metabolize hundreds of drugs, thousands of xenobiotics, and unknown numbers of …
[HTML][HTML] Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk
M Moutinho, MJ Nunes, JC Correia, MJ Gama… - Scientific reports, 2016 - nature.com
Abstract Cholesterol 24-hydroxylase (CYP46A1) is responsible for brain cholesterol
elimination and therefore plays a crucial role in the control of brain cholesterol homeostasis …
elimination and therefore plays a crucial role in the control of brain cholesterol homeostasis …
[HTML][HTML] Feasibility of Identifying Factors Related to Alzheimer's Disease and Related Dementia in Real-World Data
A comprehensive view of factors associated with AD/ADRD will significantly aid in studies to
develop new treatments for AD/ADRD and identify high-risk populations and patients for …
develop new treatments for AD/ADRD and identify high-risk populations and patients for …
Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism …
E Sezer, B Can Demirdöğen, Ş Demirkaya, G Bulut… - Neurological …, 2021 - Springer
Background Patients with multiple sclerosis (MS) have significantly lower vitamin D levels.
Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is …
Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is …