Over the past two decades, multidisciplinary investigations into the development of
nanoparticles for medical applications have continually increased. However, nanoparticles …

With over 2 million cancer cases and over 600,000 cancer-associated deaths predicted in
the US for 2022, this life-debilitating disease continuously impacts the lives of people across …

The proximity and association of cerebrospinal fluid (CSF) and the intrathecal (IT) space with
deep targets in the central nervous system (CNS) parenchyma makes IT injection an …

Increased life expectancy has led to a rise in age-related disorders including neurological
diseases such as Alzheimer's disease and Parkinson's disease. Limited progress has been …

Background: The high recurrence of glioblastoma (GB) that occurs adjacent to the resection
cavity within two years of diagnosis urges an improvement of therapies oriented to GB local …

Introduction The tight structure of the blood–brain barrier severely limits the level of drug
therapy for central nervous system disorders. In this study, a novel composite delivery …

In the past few years, there have been tremendous breakthroughs in the pharmaceutical and
drug delivery fields, with the emergence of novel technologies aiming to improve therapeutic …

Drug delivery in brain has been challenging due to the existence of blood brain barrier,
which prevents most drugs from entering the target site in brain. Compared to systematic …

Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis and high
mortality, with no curative treatment to date as limited trafficking across the blood–brain …

Localized therapy approaches have emerged as an alternative drug administration route to
overcome the limitations of systemic therapies, such as the crossing of the blood–brain …