Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

B Krause-Kyora, M Nutsua, L Boehme, F Pierini… - Nature …, 2018 - nature.com
Leprosy, a chronic infectious disease caused by Mycobacterium leprae (M. leprae), was very
common in Europe till the 16th century. Here, we perform an ancient DNA study on medieval …

Pan-genome analysis of ancient and modern Salmonella enterica demonstrates genomic stability of the invasive para C lineage for millennia

Z Zhou, I Lundstrøm, A Tran-Dien, S Duchêne… - Current Biology, 2018 - cell.com
Salmonella enterica serovar Paratyphi C causes enteric (paratyphoid) fever in humans. Its
presentation can range from asymptomatic infections of the blood stream to gastrointestinal …

Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14th century

S Waldman, D Backenroth, É Harney, S Flohr, NC Neff… - Cell, 2022 - cell.com
We report genome-wide data from 33 Ashkenazi Jews (AJ), dated to the 14 th century,
obtained following a salvage excavation at the medieval Jewish cemetery of Erfurt …

Ancient Plasmodium genomes shed light on the history of human malaria

M Michel, E Skourtanioti, F Pierini, EK Guevara… - Nature, 2024 - nature.com
Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest
selective pressures on the human genome, and resistance alleles provide biomolecular …

Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus

AK Fotakis, SD Denham, M Mackie… - … of the Royal …, 2020 - royalsocietypublishing.org
Mineralized dental plaque (calculus) has proven to be an excellent source of ancient
biomolecules. Here we present a Mycobacterium leprae genome (6.6-fold), the causative …

A seventeenth-century Mycobacterium tuberculosis genome supports a Neolithic emergence of the Mycobacterium tuberculosis complex

S Sabin, A Herbig, ÅJ Vågene, T Ahlström, G Bozovic… - Genome biology, 2020 - Springer
Background Although tuberculosis accounts for the highest mortality from a bacterial
infection on a global scale, questions persist regarding its origin. One hypothesis based on …

Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

AA Guzmán-Solís, V Villa-Islas, MJ Bravo-López… - Elife, 2021 - elifesciences.org
After the European colonization of the Americas, there was a dramatic population collapse of
the Indigenous inhabitants caused in part by the introduction of new pathogens. Although …

Paleomicrobiology: diagnosis and evolution of ancient pathogens

KI Bos, D Kühnert, A Herbig… - Annual Review of …, 2019 - annualreviews.org
The last century has witnessed progress in the study of ancient infectious disease from
purely medical descriptions of past ailments to dynamic interpretations of past population …

Shotgun metagenomic analysis reveals the prevalence of antibiotic resistance genes and mobile genetic elements in full scale hospital wastewater treatment plants

RK Manoharan, S Srinivasan, G Shanmugam… - Journal of …, 2021 - Elsevier
Wastewater treatment plants are considered as hotspots of emerging antimicrobial genes
and mobile genetic elements. We used a shotgun metagenomic approach to examine the …

[HTML][HTML] Origin and health status of first-generation Africans from early colonial Mexico

R Barquera, TC Lamnidis, AK Lankapalli, A Kocher… - Current Biology, 2020 - cell.com
The forced relocation of several thousand Africans during Mexico's historic period has so far
been documented mostly through archival sources, which provide only sparse detail on their …