Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases

GD Lewis, E Bossone, R Naeije, E Grünig, R Saggar… - Circulation, 2013 - Am Heart Assoc
The inherent assumptions of the PVR equation are that (mPAP− LAP)/CO relationships are
linear and cross the line of origin. If these assumptions are correct, PVR should be …

Chronic obstructive pulmonary disease: clinical integrative physiology

DE O'Donnell, P Laveneziana… - Clinics in chest …, 2014 - chestmed.theclinics.com
Chronic obstructive pulmonary disease (COPD) is characterized by inflammatory injury to
the intrathoracic airways, lung parenchyma, and pulmonary vasculature in highly variable …

The major limitation to exercise performance in COPD is dynamic hyperinflation

DE O'Donnell, KA Webb - Journal of applied physiology, 2008 - journals.physiology.org
The inability to engage in sustained physical activity is a common feature of chronic
obstructive pulmonary disease (COPD) and contributes importantly to the perception of poor …

Heliox improves oxygen delivery and utilization during dynamic exercise in patients with chronic obstructive pulmonary disease

GR Chiappa, F Queiroga Jr, E Meda… - American journal of …, 2009 - atsjournals.org
Rationale: Normoxic heliox (mixture of 79% He and 21% O2) may enhance exercise
tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be …

Right ventricular dysfunction in chronic lung disease

TM Kolb, PM Hassoun - Cardiology clinics, 2012 - cardiology.theclinics.com
Nearly 200 years ago, Laennec described the relationship between chronic pulmonary
disease and right ventricular (RV) dysfunction:“All diseases which give rise to severe and …

Mechanisms of dyspnoea relief and improved exercise endurance after furosemide inhalation in COPD

D Jensen, K Amjadi, V Harris-McAllister, KA Webb… - Thorax, 2008 - thorax.bmj.com
Background: This study examined the effects of inhaled furosemide on the ventilatory and
perceptual response to high-intensity constant-load cycle exercise in chronic obstructive …

Effect of heliox on heart rate kinetics and dynamic hyperinflation during high-intensity exercise in COPD

P Laveneziana, G Valli, P Onorati, P Paoletti… - European journal of …, 2011 - Springer
Respiratory mechanical abnormalities in patients with chronic obstructive pulmonary
disease (COPD) may impair cardiodynamic responses and slow down heart rate (HR) …

Bronchodilators accelerate the dynamics of muscle O2 delivery and utilisation during exercise in COPD

DC Berton, PB Barbosa, LS Takara, GR Chiappa… - Thorax, 2010 - thorax.bmj.com
Background Expiratory flow limitation and lung hyperinflation promote cardiocirculatory
perturbations that might impair O2 delivery to locomotor muscles in patients with chronic …

Bronchodilator effect on ventilatory, pulmonary gas exchange, and heart rate kinetics during high-intensity exercise in COPD

P Laveneziana, P Palange, J Ora, D Martolini… - European journal of …, 2009 - Springer
Respiratory mechanical abnormalities in patients with chronic obstructive pulmonary
disease (COPD) may impair cardiodynamic responses and convective oxygen delivery …

Effect of helium breathing on intercostal and quadriceps muscle blood flow during exercise in COPD patients

I Vogiatzis, H Habazettl, A Aliverti… - American Journal …, 2011 - journals.physiology.org
Emerging evidence indicates that, besides dyspnea relief, an improvement in locomotor
muscle oxygen delivery may also contribute to enhanced exercise tolerance following …