Hypoxia is present to some extent in most solid malignant human cancers because of an
imbalance between the limited oxygen delivery capacity of the abnormal vasculature and …

Simple Summary Prostate cancer is the most common malignancy in men, with a high
mortality rate when disease progresses to metastasis and therapeutic resistance. Evidence …

The limited efficacy of radiotherapy leads to radio‐resistance and high rates of tumor
recurrence and metastasis, which is caused by tumor hypoxia, rapid DNA damage repair …

Dose painting is the prescription of a nonuniform radiation dose distribution to the target
volume based on functional or molecular images shown to indicate the local risk of relapse …

Purpose: Tumor hypoxia is an important determinant of outcome in many human
malignancies and is associated with treatment resistance and metastases. The aim of this …

There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and
predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI …

Using a cell-based reporter gene assay, we screened a library of drugs in clinical use and
identified the anthracycline chemotherapeutic agents doxorubicin and daunorubicin as …

Interactions between cancer cells and stromal cells, including blood vessel endothelial cells
(BECs), lymphatic vessel endothelial cells (LECs), bone marrow-derived angiogenic cells …

African American men in the United States have higher mortality due to prostate cancer
(PCa) compared to other races. One reason for this disparity is the lack of in-depth …

Radiotherapy for the treatment of cancer is undergoing an evolution, shifting to the use of
heavier ion species. For a plethora of malignancies, current radiotherapy using photons or …