Contraception—retrospect and prospect
MJK Harper - Progress in Drug Research/Fortschritte der …, 1977 - Springer
Contraception as a socially aceptable custom is by and large a 20th century phenomenon
and is now perceived by many as a solution to a pressing world problem-that of …
and is now perceived by many as a solution to a pressing world problem-that of …
Mechanism of action of gestagens
BM Landgren - International Journal of Gynecology & Obstetrics, 1990 - Elsevier
In the mid-1950s it was shown that ovulation can be inhibited by oral administration of
progesterone or of synthetic progestogens such as norethynodrel. The idea that …
progesterone or of synthetic progestogens such as norethynodrel. The idea that …
The metabolic disposition of norgestrel in female rhesus monkeys.
SF Sisenwine, HB Kimmel, AL Liu… - Drug Metabolism and …, 1979 - ASPET
Following single intragastric doses of d-and dl-[24C] norgestrel (Ng), rhesus monkeys
excreted 29.5+/-2.0 (SE) and 52.6+/-5.4% of the administered radioactivity in urine. Fecal …
excreted 29.5+/-2.0 (SE) and 52.6+/-5.4% of the administered radioactivity in urine. Fecal …
Injectable depot contraceptives on d-norgestrel basis II. Clinical pharmacokinetic studies with d-norgestrel undecylate in women
J Spona, E Weiner, B Nieuweboer, M Hümpel… - Contraception, 1977 - Elsevier
The effect of a single intramuscular injection of 100 mg of d-norgestrel 17β-undecylate was
investigated in 8 women. Levels of radioimmunoassayable serum progesterone, 17β …
investigated in 8 women. Levels of radioimmunoassayable serum progesterone, 17β …
Bleeding and ovulation control with use of a small contraceptive vaginal ring releasing levonorgestrel and estradiol
J Toivonen, P Lähteenmäki, T Luukkainen - Contraception, 1979 - Elsevier
Levonorgestrel and estradiol releasing contraceptive vaginal rings (CVR) with an outer
diameter of 50 mm were used by twenty women. The treatment was given in three-week …
diameter of 50 mm were used by twenty women. The treatment was given in three-week …
The use of a contraceptive vaginal ring governed by the pattern of individual uterine bleeding
J Toivonen, P Lähteenmäki, T Luukkainen - Contraception, 1979 - Elsevier
Contraceptive vaginal rings (CVR) releasing levonorgestrel and estradiol were used for
contraceptive purposes in eight women. They were instructed to remove the CVR for five …
contraceptive purposes in eight women. They were instructed to remove the CVR for five …
Determination of plasma concentrations of d-norgestrel during a one year follow-up in women with a d-norgestrel-releasing IUD
CG Nilsson, T Luukainen, P Lähteenmäki - Contraception, 1978 - Elsevier
Eight healthy women had a d-norgestrel-releasing intrauterine device inserted
postmenstrually and maintained in the uterine cavity for a one year period. Plasma …
postmenstrually and maintained in the uterine cavity for a one year period. Plasma …
Injectable depot contraceptives on d-norgestrel basis I. Pharmacokinetic studies in dog and baboons
M Hümpel, G Kühne, PE Schulze, U Speck - Contraception, 1977 - Elsevier
Five d-norgestrel 17β-fatty acids with chain lengths of 6–16 carbon atoms were dissolved in
castor oil/benzyl benzoate (6: 4, v/v) and administered intramuscularly to dogs. The kinetics …
castor oil/benzyl benzoate (6: 4, v/v) and administered intramuscularly to dogs. The kinetics …
Release of contraceptive steroids from sustained release dosage forms and resulting plasma levels
HA Nash, DN Robertson, TM Jackanicz - Contraception, 1978 - Elsevier
The correlations of plasma levels of levonorgestrel, megestrol acetate and norgestrienone
with the doses delivered from subdermal implants and contraceptive rings have been …
with the doses delivered from subdermal implants and contraceptive rings have been …
Clinical and endocrinologic study of continuous levonorgestrel administration from subcutaneous solid polydimethylsiloxane rods
S Roy, F Stanczyk, DR Mishell Jr, M Lumkin… - Contraception, 1980 - Elsevier
Three solid polydimethylsiloxane (Silastic®) rods containing levonorgestrel were inserted
into the subcutaneous tissue of the volar aspect of the forearm of 8 women. Serum samples …
into the subcutaneous tissue of the volar aspect of the forearm of 8 women. Serum samples …