In the past decade, there has been a shift in research, clinical development, and commercial
activity to exploit the many physiological roles of RNA for use in medicine. With the rapid …

Autoimmune diseases affect tens of millions of people just in the United States alone. Most
of the available treatment options are aimed at reducing symptoms but do not lead to cures …

Autoimmune diseases affect over 4% of the world's population. Treatments are generally
palliative or use broad spectrum immunosuppressants to reduce symptoms and disease …

Regulatory T cells (Tregs) have the role of regulating self-tolerance, and suppressing
immune responses. Defects in Treg function and number can lead to in loss of tolerance or …

A nonenzymatic reaction between reducing sugars and amino groups of proteins results in
the formation of advanced glycation end products, which are linked to a number of chronic …

Behçet's disease (BD) is an uncommon autoimmune/autoinflammatory disease. Neutrophil-
to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were investigated in many …

Aberrant immune responses characterize autoimmune disorders like Rheumatoid Arthritis
(RA) wherein lymphocytes are recognized as key players. Role of CD8+ T cells in RA has …

RA is an inflammatory joint disease of an autoimmune nature, with a complex mode of
inheritance characterized by chronic and destructive inflammation in the peripheral joints of …

MicroRNAs (miRNAs) are uniquely regulated in healthy, inflamed, activated, cancerous, or
other cells and tissues of a pathological state. Many studies confirm that immune …

Folate receptor alpha (FRα) autoantibodies have been associated with fetal abnormalities
and cerebral folate deficiency-related developmental disorders. Over 70% of the children …