Amyotrophic lateral sclerosis (ALS) is the most common and most aggressive form of adult
motor neuron (MN) degeneration. The cause of the disease is still unknown, but some …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting the upper and lower motor neurones of the central nervous system. Recently, a lot …

Experimental autoimmune encephalomyelitis (EAE), an animal model for human multiple
sclerosis, is characterized by demyelination, inflammation and neurodegeneration of CNS in …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor
system. Recent work in rodent models of ALS has shown that insulin-like growth factor-1 …

Although pronounced changes in astrocytes and microglia accompany the neuronal
degeneration observed in a murine model of familial amyotrophic lateral sclerosis, the …

To study the role of one of the most potent motoneuron (MN) survival factors, glial cell line-
derived neurotrophic factor (GDNF) derived from the CNS, we generated transgenic animals …

Motor neuron diseases are neurodegenerative diseases that predominantly affect the
neuromuscular system. To date, there are no valid therapeutic treatments for such diseases …

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons
(MNs), and is considered a potential agent for the treatment of amyotrophic lateral sclerosis …

Primary motor neurons are difficult to study in conventional culture systems because of their
short‐term survival without trophic support from glia. In addition, axonal migration on a two …

All-trans-retinoic Acid (atRA) is the principal active metabolite of Vitamin A, essential for
various biological processes. The activities of atRA are mediated by nuclear RA receptors …