The unusual regenerative properties of the liver are a logical adaptation by organisms, as
the liver is the main detoxifying organ of the body and is likely to be injured by ingested …

CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that all
contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

During embryogenesis, endothelial cells induce organogenesis before the development of
circulation,,,. These findings suggest that endothelial cells not only form passive conduits to …

Alzheimer's disease (AD) is the most common dementia. It is known that women with one
ApoE4 allele display greater risk and earlier onset of AD compared with men. In mice, we …

The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or
hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while …

Growth-arrested 3T3-L1 preadipocytes rapidly express CCAAT/enhancer-binding protein-β
(C/EBPβ) upon hormonal induction of differentiation. However, the DNA binding activity of …

Genetic analysis in mice has demonstrated a crucial role of the Met tyrosine kinase receptor
and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), in development of the liver …

During'emergency'situations such as infections, host defense requires rapid mobilization of
bone marrow granulocyte progenitors.'Steady-state'granulopoiesis is absolutely dependent …

Complement has been implicated in liver repair after toxic injury. Here, we demonstrate that
complement components are essential for liver regeneration, and mediate their effect by …