[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential
P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …
particular interest due to distinctive properties including a normal restricted expression …
[HTML][HTML] COPDGene® 2019: redefining the diagnosis of chronic obstructive pulmonary disease
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of
morbidity and mortality. Present-day diagnostic criteria are largely based solely on …
morbidity and mortality. Present-day diagnostic criteria are largely based solely on …
The role of hyperpolarized 129xenon in MR imaging of pulmonary function
In the last two decades, functional imaging of the lungs using hyperpolarized noble gases
has entered the clinical stage. Both helium (3 He) and xenon (129 Xe) gas have been …
has entered the clinical stage. Both helium (3 He) and xenon (129 Xe) gas have been …
[HTML][HTML] Machine-learning algorithm-based prediction of diagnostic gene biomarkers related to immune infiltration in patients with chronic obstructive pulmonary …
Y Zhang, R Xia, M Lv, Z Li, L Jin, X Chen… - Frontiers in …, 2022 - frontiersin.org
Objective This study aims to identify clinically relevant diagnostic biomarkers in chronic
obstructive pulmonary disease (COPD) while exploring how immune cell infiltration …
obstructive pulmonary disease (COPD) while exploring how immune cell infiltration …
[HTML][HTML] A 3D-CNN model with CT-based parametric response mapping for classifying COPD subjects
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder involving
abnormalities of lung parenchymal morphology with different severities. COPD is assessed …
abnormalities of lung parenchymal morphology with different severities. COPD is assessed …
Effect of indacaterol/glycopyrronium on pulmonary perfusion and ventilation in hyperinflated patients with chronic obstructive pulmonary disease (CLAIM). A double …
J Vogel-Claussen, CO Schönfeld, TF Kaireit… - American journal of …, 2019 - atsjournals.org
Rationale: In the CLAIM study, dual bronchodilation with indacaterol/glycopyrronium
(IND/GLY) significantly reduced hyperinflation, which translated into improved cardiac …
(IND/GLY) significantly reduced hyperinflation, which translated into improved cardiac …
Free-breathing Dynamic 19F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD
M Gutberlet, TF Kaireit, A Voskrebenzev, F Lasch… - Radiology, 2018 - pubs.rsna.org
Purpose To quantify regional lung ventilation in patients with chronic obstructive pulmonary
disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas …
disease (COPD) by using free-breathing dynamic fluorinated (fluorine 19 [19F]) gas …
Present and future utility of computed tomography scanning in the assessment and management of COPD
K Ostridge, TMA Wilkinson - European Respiratory Journal, 2016 - Eur Respiratory Soc
Computed tomography (CT) is the modality of choice for imaging the thorax and lung
structure. In chronic obstructive pulmonary disease (COPD), it used to recognise the key …
structure. In chronic obstructive pulmonary disease (COPD), it used to recognise the key …
[HTML][HTML] Quantification of pulmonary functional MRI: state-of-the-art and emerging image processing methods and measurements
M Sharma, PV Wyszkiewicz… - Physics in Medicine …, 2022 - iopscience.iop.org
Pulmonary functional magnetic resonance imaging (PfMRI) provides a way to non-invasively
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …
map and measure the spatial distribution of pulmonary ventilation, perfusion and gas …
Identification of COPD from multi-view snapshots of 3D lung airway tree via deep CNN
Chronic obstructive pulmonary disease (COPD) is associated with morphologic
abnormalities of airways with various patterns and severities. However, the way of effectively …
abnormalities of airways with various patterns and severities. However, the way of effectively …