Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at
epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating …

Trigeminal neuralgia (TN) has been described in the literature as one of the most debilitating
presentations of orofacial pain. This review summarizes over 150 years of collective clinical …

In biomedical sciences, the function of a protein of interest is investigated by altering its net
activity and assessing the consequences for the cell or organism. To change the activity of a …

Despite the importance of pain as a warning physiological system, chronic neuropathic pain
is frequently caused by damage in the nervous system, followed by persistence over a long …

The diagnostic criteria published by the PNS (Paraneoplastic Neurological Syndromes)
Euronetwork in 2004 provided a useful classification of PNS, including paraneoplastic …

Neuropathic pain, a type of chronic and potentially disabling pain resulting from primary
injury/dysfunction of the somatosensory nervous system and spinal cord injury, is one of the …

Topical lidocaine is widely used in current practice for a variety of pain conditions. This
literature review shows that its limited absorption and relative lack of systemic adverse …

Interest in and use of topical analgesics has been increasing, presumably due to their
potential utility for relief of acute and chronic pain. Topically applied agents with analgesic …

Neuropathic pain results from lesions or diseases of the somatosensory nervous system and
it remains largely difficult to treat. Peripheral neuropathic pain originates from injury to the …

With sweeping advances in precision delivery systems and manipulation of the genomes
and transcriptomes of various cell types, medical biotechnology offers unprecedented …