The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

Background & Aims: The irritable bowel syndrome (IBS) is a common disorder characterized
by abdominal pain in the setting of altered perception of viscerosensory stimuli. This so …

1. Introduction......................................... II. Anatomy and physiology................................ A. The
peripheral apparatus............................. Fiber composition of muscle nerves …

IN homeothermic species, a thermoregulatory system coordinates defenses against cold
and heat to maintain internal body temperature within a narrow range, thus optimizing …

The mammalian central nervous system possesses well-defined networks that modulate
nociceptive transmission. The most extensively studied are the networks that underlie …

Chronically painful conditions are frequently associated with sleep disturbances, ie changes
in sleep continuity and sleep architecture as well as increased sleepiness during daytime. A …

Although opioids are highly effective for the treatment of pain, they are also known to be
intensely addictive. There has been a massive research investment in the development of …

The aim of this study was to examine the efficacy and safety of duloxetine, a balanced and
potent dual reuptake inhibitor of serotonin and norepinephrine, in the management of …

Humans have developed a number of specific mechanisms that allow us to maintain much
larger social networks than would be expected given our brain size. For our primate cousins …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …