Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …

The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Cancer cells are frequently confronted with metabolic stress in tumor microenvironments
due to their rapid growth and limited nutrient supply. Metabolic stress induces cell death …

Obesity is a major risk factor for insulin resistance and type 2 diabetes. In adipose tissue,
obesity-mediated insulin resistance correlates with the accumulation of proinflammatory …

Aging is a natural phenomenon that occurs in all living organisms. In humans, aging is
associated with lowered overall functioning and increased mortality out of the risk for various …

Autophagy, originally found in liver experiments, is a cellular process that degrades
damaged organelle or protein aggregation. This process frees cells from various stress …

Metabolism research is undergoing a renaissance because many diseases are increasingly
recognized as being characterized by perturbations in intracellular metabolic regulation …