Macroencapsulated bacteria for in vivo sensing and therapeutics

Y Lyu, H Huang, Y Su, B Ying, WC Liu, K Dong, N Du… - Matter, 2024 - cell.com
Engineered bacteria are increasingly recognized as sustained and intelligent sources for
sensing and therapeutics due to their unique capabilities such as in situ multiplication, tissue …

The Gram-negative permeability barrier: tipping the balance of the in and the out

C Maher, KA Hassan - Mbio, 2023 - Am Soc Microbiol
Gram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the
permeability barrier formed by their cell envelope. The complex and synergistic interplay of …

In Situ Self‐Aggregation of Spirulina Skeleton Fibers Enhances the Efficacy of Anti‐Tumor Thermal Immunotherapy

YD Qi, ZN Zhuang, SM Zeng, Y Tang… - Advanced Functional …, 2024 - Wiley Online Library
The lack of broad‐spectrum tumor antigens, limited immunogenicity of antigens, and
immunosuppressive microenvironment in tumors have impeded the development of cancer …

Epitopes in the capsular polysaccharide and the porin OmpK36 receptors are required for bacteriophage infection of Klebsiella pneumoniae

RA Dunstan, RS Bamert, KS Tan, U Imbulgoda… - Cell Reports, 2023 - cell.com
To kill bacteria, bacteriophages (phages) must first bind to a receptor, triggering the release
of the phage DNA into the bacterial cell. Many bacteria secrete polysaccharides that had …

Tunable force transduction through the Escherichia coli cell envelope

DP Williams-Jones, MN Webby… - Proceedings of the …, 2023 - National Acad Sciences
The outer membrane (OM) of Gram-negative bacteria is not energised and so processes
requiring a driving force must connect to energy-transduction systems in the inner …

Streptomyces extracellular vesicles are a broad and permissive antimicrobial packaging and delivery system

KJ Meyer, JR Nodwell - Journal of Bacteriology, 2024 - Am Soc Microbiol
Streptomyces are the primary source of bioactive specialized metabolites used in research
and medicine, including many antimicrobials. These are presumed to be secreted and …

Molecular Machines that Facilitate Bacterial Outer Membrane Protein Biogenesis

MT Doyle, HD Bernstein - Annual Review of Biochemistry, 2024 - annualreviews.org
Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …

Synergistic Approaches for Enhanced Light-Driven Hydrogen Production: A Membrane-Anchoring Protein-Engineered Biohybrid System with Dual Photosensitizers …

H Li, X Yu, Y Qin, T Jiang, J Wang, Z Cai, J Xu… - ACS Materials …, 2024 - ACS Publications
Sunlight-driven hydrogen production provides a sustainable solution for clean energy
generation. Despite their potential, extracellular photosensitized biohybrid systems are …

Shigella flexneri Adapts to Niche-Specific Stresses through Modifications in Cell Envelope Composition and Decoration

A Ascari, JK Waters, R Morona… - ACS Infectious …, 2023 - ACS Publications
Shigella flexneri is the primary causative agent of worldwide shigellosis. As the pathogen
transverses the distinct niches of the gastrointestinal tract it necessitates dynamic adaptation …

The TAM, a Translocation and Assembly Module for protein assembly and potential conduit for phospholipid transfer

KJ Goh, CJ Stubenrauch, T Lithgow - EMBO reports, 2024 - embopress.org
The assembly of β-barrel proteins into the bacterial outer membrane is an essential process
enabling the colonization of new environmental niches. The TAM was discovered as a …