The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for
brain processes, including learning and memory. Increasing evidence indicates that …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

Females are more likely than males to develop post-traumatic stress disorder (PTSD).
However, the neurobiological mechanisms responsible for these sex differences remain …

Even though significant efforts have been spent in recent years to understand and define the
determinants of in vivo potency and clearance, important pieces of information are still …

Background Sex differences have been observed in several brain regions for the molecular
mechanisms involved in baseline (resting) and memory-related processes. The ubiquitin …

Strong evidence has implicated proteasome-mediated protein degradation in the memory
consolidation process. However, due to the use of pharmacological approaches, the cell …

The ubiquitin proteasome system (UPS) is a primary mechanism through which proteins are
degraded in cells. UPS activity in the dorsal hippocampus (DH) is necessary for multiple …

There is now ample evidence that the strength and underlying mechanisms of memory
formation can be drastically altered by prior experience. However, the prior work using …

Sex steroid hormones such as 17β-estradiol (E2) are critical neuromodulators of
hippocampal synaptic plasticity and hippocampus-dependent memory in both males and …

Fear memory retrieval is relevant to psychiatric disorders such as post-traumatic stress
disorder (PTSD). One of the hallmark symptoms of PTSD is the repeated retrieval and re …