The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …

Microorganisms play a dominant role in the biogeochemical cycling of nutrients. They are
rightly praised for their facility for fixing both carbon and nitrogen into organic matter, and …

Multi-component signal transduction pathways and gene regulatory circuits underpin
integrated cellular responses to perturbations. A recurring set of network motifs serve as the …

Oscillations pervade biological systems at all scales. In bacteria, oscillations control
fundamental processes, including gene expression, cell cycle progression, cell division …

The creation of protein from DNA is a dynamic process consisting of numerous reactions,
such as transcription, translation and protein folding. Each of these reactions is further …

Transcriptional delay can significantly impact the dynamics of gene networks. Here we
examine how such delay affects bistable systems. We investigate several stochastic models …

Background Aspergillus fumigatus is a ubiquitous airborne fungal pathogen that presents a
life-threatening health risk to individuals with weakened immune systems. A. fumigatus …

The timing of a cellular event often hides critical information on the process leading to the
event. Our ability to measure event times in single cells along with other quantities allow us …

Delay is an important and ubiquitous aspect of many biochemical processes. For example,
delay plays a central role in the dynamics of genetic regulatory networks as it stems from the …

Post-transcriptional regulatory processes may change transcript levels and affect cell-to-cell
variability or noise. We study small-RNA downregulation to elucidate its effects on noise in …