It is well‐accepted that off‐label drug dosing recommendations for pediatric patients should
be based on the best available evidence. However, the available traditional evidence is …

Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …

Diazepam and lorazepam are two benzodiazepine drugs widely prescribed as
antidepressants and antiepileptics. A straightforward and time-save dispersive micro solid …

The development of pediatric oral drugs is hampered by a lack of predictive simulation tools.
These tools, in turn, require data on the physiological variables that influence oral drug …

Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal
reflux disease, a condition that disproportionately affects children with obesity. Appropriately …

Introduction Critically ill patients show large variability in drug disposition due to eg, age,
size, disease and treatment modalities. Physiologically-based pharmacokinetic (PBPK) …

Introduction Modeling and simulation can support dosing recommendations for clinical
practice, but a simple framework is missing. In this proof-of-concept study, we aimed to …

Abstract Background and Objective With the rise in the use of physiologically based
pharmacokinetic (PBPK) modeling over the past decade, the use of PBPK modeling to …

Background Antenatal betamethasone and dexamethasone are prescribed to women who
are at high risk of premature birth to prevent neonatal respiratory distress syndrome (RDS) …

The rapid onset of action of nifedipine causes a precipitous reduction in blood pressure
leading to adverse effects associated with reflex sympathetic nervous system (SNS) …