Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

A Agustí, E Melén, DL DeMeo… - The Lancet …, 2022 - thelancet.com
The traditional view of chronic obstructive pulmonary disease (COPD) as a self-inflicted
disease caused by tobacco smoking in genetically susceptible individuals has been …

Update on the pathogenesis of chronic obstructive pulmonary disease

A Agustí, JC Hogg - New England Journal of Medicine, 2019 - Mass Medical Soc
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision

B Celli, L Fabbri, G Criner, FJ Martinez… - American journal of …, 2022 - atsjournals.org
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

COPD 2020: changes and challenges

A Agustí, C Vogelmeier… - American Journal of …, 2020 - journals.physiology.org
3 Chronic obstructive pulmonary disease (COPD) is a major global health problem due to 26
its high prevalence (about 10% of the adult population), raising incidence (related in 27 part …

Early COPD: current evidence for diagnosis and management

A Fazleen, T Wilkinson - Therapeutic advances in respiratory …, 2020 - journals.sagepub.com
Chronic obstructive pulmonary disease (COPD) affects one-tenth of the world's population
and has been identified as a major global unmet health need by the World Health …

Role of short-chain fatty acids produced by gut microbiota in innate lung immunity and pathogenesis of the heterogeneous course of chronic obstructive pulmonary …

S Kotlyarov - International Journal of Molecular Sciences, 2022 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a widespread socially significant disease.
The development of COPD involves the innate immune system. Interestingly, the regulation …

COPD: time to improve its taxonomy?

BR Celli, A Agustí - ERJ open research, 2018 - Eur Respiratory Soc
Due to well-conducted epidemiological studies and advances in genetics, molecular
biology, translational research, the advent of computed tomography of the lungs and …

Malnutrition according to ESPEN consensus predicts hospitalizations and long-term mortality in rehabilitation patients with stable chronic obstructive pulmonary …

E Marco, D Sánchez-Rodríguez, VN Dávalos-Yerovi… - Clinical nutrition, 2019 - Elsevier
Background Nutritional disorders are frequent in patients with chronic pulmonary obstructive
disease (COPD) and have negative health impacts. This study aimed to explore the value of …

Disease trajectories and impact of one moderate exacerbation in GOLD B COPD patients

A Løkke, O Hilberg, P Lange, R Ibsen… - … journal of chronic …, 2022 - Taylor & Francis
Introduction Studies have shown that exacerbation in chronic obstructive pulmonary disease
(COPD) increases the risk of further exacerbations. Our aim was to investigate the impact of …

Review of drug development guidance to treat chronic obstructive pulmonary disease: US and EU perspectives

A van Haarst, L McGarvey… - Clinical Pharmacology & …, 2019 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) remains a leading cause of death
worldwide, yet only one new drug class has been approved in the last decade. However …