Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …

Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

Air pollution is associated with detrimental effects on human health, including decreased
cardiovascular function. However, the causative mechanisms behind these effects have yet …

Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

The development of novel drugs specifically directed at the ion channels underlying
particular features of cardiac action potential (AP) initiation, recovery, and refractoriness …

The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …

In recent decades, the scientific community has seen an increased interest in rigor and
reproducibility. In 2017, concerns about methodological thoroughness and reporting …

Diabetes mellitus affects the heart through various mechanisms such as microvascular
defects, metabolic abnormalities, autonomic dysfunction and incompatible immune …