Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

X Wu, M Xu, M Geng, S Chen, PJ Little, S Xu… - Signal transduction and …, 2023 - nature.com
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms

K Huang, X Luo, B Liao, G Li, J Feng - Cardiovascular Diabetology, 2023 - Springer
Among the complications of diabetes, cardiovascular events and cardiac insufficiency are
considered two of the most important causes of death. Experimental and clinical evidence …

Oxidative stress and lipid mediators modulate immune cell functions in autoimmune diseases

P Wójcik, A Gęgotek, N Žarković… - International journal of …, 2021 - mdpi.com
Autoimmune diseases, including psoriasis, systemic lupus erythematosus (SLE), and
rheumatic arthritis (RA), are caused by a combination of environmental and genetic factors …

Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota

X Yang, D Li, M Zhang, Y Feng, X Jin, D Liu… - Journal of Animal …, 2023 - Springer
Background Ginkgo biloba extract (GBE) is evidenced to be effective in the prevention and
alleviation of metabolic disorders, including obesity, diabetes and fatty liver disease …

Angelica polysaccharide antagonizes 5-FU-induced oxidative stress injury to reduce apoptosis in the liver through Nrf2 pathway

D Zeng, Y Wang, Y Chen, D Li, G Li, H Xiao… - Frontiers in …, 2021 - frontiersin.org
Oxidative stress induced by chemotherapeutic agents causes hepatotoxicity. 5-Fluorouracil
(5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and the …

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats

Y Feng, S Gao, T Zhu, G Sun, P Zhang, Y Huang… - Frontiers in …, 2022 - frontiersin.org
Context Hyperlipidemia is a highly prevalent risk factor for atherosclerosis and stroke. The
currently available medications used to treat Hyperlipidemia cannot improve its oxidative …

Platelet function in CKD: a systematic review and meta-analysis

CC Baaten, M Sternkopf, T Henning… - Journal of the …, 2021 - journals.lww.com
Background Patients with CKD are at high risk for thrombotic and hemorrhagic
complications. Abnormalities in platelet function are central to these complications, but …

Catechins: Protective mechanism of antioxidant stress in atherosclerosis

Y Sheng, Y Sun, Y Tang, Y Yu, J Wang… - Frontiers in …, 2023 - frontiersin.org
Tea has long been valued for its health benefits, especially its potential to prevent and treat
atherosclerosis (AS). Abnormal lipid metabolism and oxidative stress are major factors that …

Effects of pyrroloquinoline quinone on lipid metabolism and anti-oxidative capacity in a high-fat-diet metabolic dysfunction-associated fatty liver disease chick model

K Qiu, Q Zhao, J Wang, GH Qi, SG Wu… - International Journal of …, 2021 - mdpi.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) and its interaction with many
metabolic pathways raises global public health concerns. This study aimed to determine the …

Dual role of cadmium in rat liver: Inducing liver injury and inhibiting the progression of early liver cancer

H Zhang, J Yan, Y Xie, X Chang, J Li, C Ren, J Zhu… - Toxicology Letters, 2022 - Elsevier
The heavy metal cadmium (Cd) can induce damage in liver and liver cancer cells; however,
the mechanism underlying its toxicity needs to be further verified in vivo. We daily …