It has been over a century since Carlos Chagas discovered the Trypanosoma cruzi (T. cruzi)
as the causative agent of Chagas disease (CD), a neglected tropical disease with several …

Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

Trypanosoma cruzi is the etiologic agent of Chagas disease, which is estimated to affect
over eight million people around the world. Trypanosoma cruzi has a complex life cycle …

Improving the solubility of polysubstituted 1, 4-naphthoquinone derivatives was achieved by
introducing nitrogen in two different positions of the naphthoquinone core, at C-5 and at C-8 …

Quinones are important scaffolds that are present in a variety of natural products or synthetic
bioactive molecules. Arylation is an important strategy for accomplishing structural …

Chagas' disease, or American trypanosomosiasis, has been the most relevant illness
produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided …

Chagas disease (CD) still represents a serious public health problem in Latin America, even
after more than 100 years of its discovery. Clinical treatments (nifurtimox and benznidazole) …

Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids
Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., respectively, are considered …

Lipoamide dehydrogenase (LipDH) is a component of four mitochondrial multienzyme
complexes. RNA interference or the deletion of both alleles in bloodstream Trypanosoma …

Nitroheterocyclic prodrugs are used to treat infections caused by Trypanosoma cruzi and
Trypanosoma brucei. A key component in selectivity involves a specific activation step …