This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

A large body of evidence has appeared over the last 6 years suggesting that nitric oxide
biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia …

Background and Purpose—During focal cerebral ischemia, the ischemic penumbra or
border-zone regions of moderate cortical blood flow reductions have a heterogeneous …

Background People with hyperglycaemia concomitant with an acute stroke have greater
mortality, stroke severity, and functional impairment when compared with those with …

Glutathione is a key cellular antioxidant that is contained in both cytoplasmic and
mitochondrial compartments. Previous investigations indicate that depletion of the …

The purpose of this study was to investigate the mechanisms by which a nitric oxide
synthase (NOS) inhibitor, NG-nitro-l-arginine methyl ester (l-NAME), is neuroprotective in the …

An important factor for successful translational stroke research is study quality. Low-quality
studies are at risk of biased results and effect overestimation, as has been intensely …

In the present study we investigated the effect of acute administration of l-arginine (Arg) on
hippocampal Na+, K+-ATPase activity and on retrieval of step-down inhibitory avoidance in …

Background. Ischemia/reperfusion injury, and thus graft pancreatitis, remains a major
problem in pancreas transplantation. Contradictory results about the role of nitric oxide (NO) …

This is the first report on increased neuronal levels of biliverdin reductase (BVR) in response
to ischemic brain injury. BVR is an oxidoreductase, and is unique among all enzymes …