Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that
mediates a broad spectrum of (patho) physiological processes in response to numerous …

The coordinated movement of organic anions (eg, drugs, metabolites, signaling molecules,
nutrients, antioxidants, gut microbiome products) between tissues and body fluids depends …

The understanding of disease etiology and pathogenesis has radically changed as a
consequence of the new challenges posed by climate change, environmental degradation …

The aryl hydrocarbon receptor (AHR) signaling pathway is a complex regulatory network
that plays a critical role in various biological processes, including cellular metabolism …

Elevation of reactive oxygen species (ROS) levels is a general consequence of tumor cells'
response to treatment and may cause tumor cell death. Mechanisms by which tumor cells …

Adverse outcome pathways (AOPs) are formalized and structured linear concepts that
connect one molecular initiating event (MIE) to an adverse outcome (AO) via different key …

The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that is well-known
for regulating xenobiotic metabolism. Studies in knockout and transgenic mice indicate that …

Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …