[HTML][HTML] Epidemic and pandemic viral infections: impact on tuberculosis and the lung: A consensus by the World Association for Infectious Diseases and …

CWM Ong, GB Migliori, M Raviglione… - European …, 2020 - Eur Respiratory Soc
Major epidemics, including some that qualify as pandemics, such as severe acute
respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV, influenza A …

QuantiFERON TB Gold Plus for the diagnosis of tuberculosis: a systematic review and meta-analysis

G Sotgiu, L Saderi, E Petruccioli, S Aliberti, A Piana… - Journal of Infection, 2019 - Elsevier
Estimated 2017 tuberculosis (TB) incidence is 10 million and mainly depends on the
reservoir of individuals with latent TB infection (LTBI). QuantiferonⓇ-TB Gold in-Tube (QFT …

[HTML][HTML] Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2

L Petrone, E Petruccioli, V Vanini, G Cuzzi… - International journal of …, 2021 - Elsevier
Objectives The interaction of COVID-19 and tuberculosis (TB) are still poor characterized.
Here we evaluated the immune response specific for Micobacterium tuberculosis (Mtb) and …

[HTML][HTML] Spike is the most recognized antigen in the whole-blood platform in both acute and convalescent COVID-19 patients

A Aiello, SN Fard, E Petruccioli, L Petrone… - International Journal of …, 2021 - Elsevier
Objectives To identify the best experimental approach to detect a SARS-CoV-2-specific T
cell response using a whole-blood platform. Methods Whole-blood from 56 COVID-19 and …

Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis molecular bacterial load assay

W Sabiiti, K Azam, ECW Farmer, D Kuchaka, B Mtafya… - Thorax, 2020 - thorax.bmj.com
In this comparative biomarker study, we analysed 1768 serial sputum samples from 178
patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load …

Biomarkers that correlate with active pulmonary tuberculosis treatment response: a systematic review and meta-analysis

AJ Zimmer, F Lainati, N Aguilera Vasquez… - Journal of clinical …, 2022 - Am Soc Microbiol
Current WHO recommendations for monitoring treatment response in adult pulmonary
tuberculosis (TB) are sputum smear microscopy and/or culture conversion at the end of the …

[HTML][HTML] Antibody subclass and glycosylation shift following effective TB treatment

PS Grace, S Dolatshahi, LL Lu, A Cain… - Frontiers in …, 2021 - frontiersin.org
With an estimated 25% of the global population infected with Mycobacterium tuberculosis
(Mtb), tuberculosis (TB) remains a leading cause of death by infectious diseases. Humoral …

[HTML][HTML] Tools to implement the World Health Organization End TB Strategy: Addressing common challenges in high and low endemic countries

S Al Abri, T Kasaeva, GB Migliori, D Goletti… - International Journal of …, 2020 - Elsevier
Aim The purpose of this viewpoint is to summarize the advantages and constraints of the
tools and strategies available for reducing the annual incidence of tuberculosis (TB) by …

Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis‐specific CD4 T‐cell phenotype regardless of HIV‐1 status

C Riou, E Du Bruyn, S Ruzive… - Clinical & …, 2020 - Wiley Online Library
Objectives The development of non‐sputum‐based assays for tuberculosis (TB) diagnosis
and treatment monitoring is a key priority. Recent data indicate that whole blood‐based …

[HTML][HTML] Multi-country evaluation of RISK6, a 6-gene blood transcriptomic signature, for tuberculosis diagnosis and treatment monitoring

R Bayaa, MDB Ndiaye, C Chedid, E Kokhreidze… - Scientific Reports, 2021 - nature.com
There is a crucial need for non-sputum-based TB tests. Here, we evaluate the performance
of RISK6, a human-blood transcriptomic signature, for TB screening, triage and treatment …