Antibiotic resistance and persistence—Implications for human health and treatment perspectives
Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of
treatment failure and relapsing infections. They are thus important drivers of increased …
treatment failure and relapsing infections. They are thus important drivers of increased …
The stringent response and physiological roles of (pp) pGpp in bacteria
SE Irving, NR Choudhury, RM Corrigan - Nature Reviews Microbiology, 2021 - nature.com
The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …
Transcriptional responses to ppGpp and DksA
RL Gourse, AY Chen, S Gopalkrishnan… - Annual review of …, 2018 - annualreviews.org
The stringent response to nutrient deprivation is a stress response found throughout the
bacterial domain of life. Although first described in proteobacteria for matching ribosome …
bacterial domain of life. Although first described in proteobacteria for matching ribosome …
(p) ppGpp and its role in bacterial persistence: new challenges
Antibiotic failure not only is due to the development of resistance by pathogens but can also
often be explained by persistence and tolerance. Persistence and tolerance can be included …
often be explained by persistence and tolerance. Persistence and tolerance can be included …
In Vitro Studies of Persister Cells
N Kaldalu, V Hauryliuk, KJ Turnbull… - Microbiology and …, 2020 - Am Soc Microbiol
Many bacterial pathogens can permanently colonize their host and establish either chronic
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …
or recurrent infections that the immune system and antimicrobial therapies fail to eradicate …
(p) ppGpp and the stringent response: an emerging threat to antibiotic therapy
JK Hobbs, AB Boraston - ACS infectious diseases, 2019 - ACS Publications
In 1969, Cashel and Gallant first observed the presence of (p) ppGpp—the signaling
molecule of the stringent response—in starved bacterial cells. Fifty years later,(p) ppGpp and …
molecule of the stringent response—in starved bacterial cells. Fifty years later,(p) ppGpp and …
Bacterial Multicellularity: The Biology of Escherichia coli Building Large-Scale Biofilm Communities
Biofilms are a widespread multicellular form of bacterial life. The spatial structure and
emergent properties of these communities depend on a polymeric extracellular matrix …
emergent properties of these communities depend on a polymeric extracellular matrix …
Modeling the postmerger gravitational wave signal and extracting binary properties from future binary neutron star detections
KW Tsang, T Dietrich, C Van Den Broeck - Physical Review D, 2019 - APS
Gravitational wave astronomy has established its role in measuring the equation of state
governing cold supranuclear matter. To date and in the near future, gravitational wave …
governing cold supranuclear matter. To date and in the near future, gravitational wave …
Nutrient availability as an arbiter of cell size
DR Kellogg, PA Levin - Trends in cell biology, 2022 - cell.com
Pioneering work carried out over 60 years ago discovered that bacterial cell size is
proportional to the growth rate set by nutrient availability. This relationship is traditionally …
proportional to the growth rate set by nutrient availability. This relationship is traditionally …
Linking bacterial growth, survival, and multicellularity–small signaling molecules as triggers and drivers
R Hengge - Current Opinion in Microbiology, 2020 - Elsevier
Highlights•Growth versus maintenance/resilience is the overarching theme of cellular
regulation.•Why transition to multicellularity is integrated into the growth-versus-survival …
regulation.•Why transition to multicellularity is integrated into the growth-versus-survival …