▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

In addition to their well known roles within cells, purine nucleotides such as adenosine 5′
triphosphate (ATP) and guanosine 5′ triphosphate (GTP), nucleosides such as adenosine …

Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …

Adenosine A2A receptors, abundantly expressed on striatal medium spiny neurons, appear
to activate signaling cascades implicated in the regulation of coexpressed ionotropic …

Adenosine produces a wide variety of physiological effects through the activation of cell
surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor …

The adenosine A2A receptor has been implicated in the underlying biology of various
neurological and psychiatric disorders, including Parkinson's disease (PD) and depression …

Numerous studies have consistently shown that agonist stimulation of adenosine A1
receptors results in a significant reduction of morbidity and mortality associated with global …

Recent advances in molecular biology, biochemistry, cell biology and behavioral
pharmacology together with the development of more selective ligands to the various …