1 In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in
the cerebral cortex by systemic hypoxia (breathing 8% O2). Red cell flux was recorded from …

Rationale: Caffeine is a non-selective A 1/A 2 adenosine receptor antagonist which is known
to improve cognitive performance in humans. This effect of caffeine has been attributed to its …

The adenosine antagonist 9-chloro-2-(2-furanyl)[1, 2, 4] triazolo [1, 5-c] quinazolin-5-amine
(CGS 15943) binds nonselectively to human A1, A2A, and A3 receptors with high affinity …

The antipsychotic drug, haloperidol, elicits the expression of neurotensin and c-fos mRNA in
the dorsal lateral region of the striatum and produces an acute cataleptic response in …

The adenosine A2A receptor (A2AR) is in the center of a neuromodulatory network affecting
a wide range of neuropsychiatric functions by interacting with and integrating several …

Abstract Adenosine A2A receptors (A2ARs) are highly expressed in the human striatum, and
at lower densities in the cerebral cortex, the hippocampus, and cells of the immune system …

As a member of neurotrophin family, brain derived neurotrophic factor (BDNF) plays critical
roles in neuronal development, differentiation, synaptogenesis, and neural protection from …

Adenosine can influence dopaminergic neuro‐transmission in the basal ganglia via
postsynaptic inter‐action between adenosine A2A and dopamine D2 receptors. We have …

Chronic treatment with opioids induces adaptations in neurons leading to tolerance and
dependence. Studies have implicated the midbrain periaqueductal gray (PAG) in the …

The activation of adenosine Al, A2 and A3 receptors can protect neurones against damage
generated by mechanical or hypoxic/ischaemic insults as well as excitotoxins. Al receptors …