The microenvironment of established tumours is often immunosuppressed, and this allows
tumours to grow and disseminate without being eliminated by the patient's immune system …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …

There is a growing body of evidence suggesting that alterations in the adhesion properties
of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes …

The ability of cells to regulate dynamically their adhesion to one another and to the
extracellular matrix (ECM) that surrounds them is essential in multicellular organisms. The …

Notch and its ligands play critical roles in cell fate determination. Expression of Notch and
ligand in vascular endothelium and defects in vascular phenotypes of targeted mutants in …

Inhibition of αvβ3 or αvβ5 integrin function has been reported to suppress
neovascularization and tumor growth, suggesting that these integrins are critical modulators …

The motility and morphogenesis of endothelial cells is controlled by spatio-temporally
regulated activation of integrin adhesion receptors, and integrin activation is stimulated by …

Akt kinases control essential cellular functions, including proliferation, apoptosis,
metabolism and transcription, and have been proposed as promising targets for treatment of …

Crosstalk between integrins and growth factor receptors are an important signaling
mechanism to provide specificity during normal development and pathological processes in …

Integrin activation is essential for dynamically linking the extracellular environment and
cytoskeletal/signaling networks. Activation is controlled by integrins' short cytoplasmic tails …