[HTML][HTML] Insulin-like growth factors: Ligands, binding proteins, and receptors
Background The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin),
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …
receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1 …
Extracellular matrix regulation of fibroblast function: redefining our perspective on skin aging
The dermal extracellular matrix (ECM) comprises the bulk of skin and confers strength and
resiliency. In young skin, fibroblasts produce and adhere to the dermal ECM, which is …
resiliency. In young skin, fibroblasts produce and adhere to the dermal ECM, which is …
Overview of the matrisome—an inventory of extracellular matrix constituents and functions
RO Hynes, A Naba - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
Completion of genome sequences for many organisms allows a reasonably complete
definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core …
definition of the complement of extracellular matrix (ECM) proteins. In mammals this “core …
Role of age-associated alterations of the dermal extracellular matrix microenvironment in human skin aging: a mini-review
T Quan, GJ Fisher - Gerontology, 2015 - karger.com
Human skin is largely composed of a collagen-rich connective tissue, which provides
structural and functional support. The collagen-rich connective tissue is produced …
structural and functional support. The collagen-rich connective tissue is produced …
Immunomodulatory role of the extracellular matrix within the liver disease microenvironment
CE McQuitty, R Williams, S Chokshi… - Frontiers in …, 2020 - frontiersin.org
Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis
KE Lipson, C Wong, Y Teng, S Spong - Fibrogenesis & tissue repair, 2012 - Springer
CTGF is a secreted matricellular protein with very complex biology. It has been shown to
modulate many signaling pathways leading to cell adhesion and migration, angiogenesis …
modulate many signaling pathways leading to cell adhesion and migration, angiogenesis …
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
Cellular senescence is a recognized mechanism of tumour suppression; however, its
contribution to other pathologies is not well understood. We show that the matricellular …
contribution to other pathologies is not well understood. We show that the matricellular …
Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets
Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …
and have important roles in inflammation, wound healing and injury repair in adulthood …
Characterization of a novel chicken muscle disorder through differential gene expression and pathway analysis using RNA-sequencing
Background Improvements in poultry production within the past 50 years have led to
increased muscle yield and growth rate, which may be contributing to an increased rate and …
increased muscle yield and growth rate, which may be contributing to an increased rate and …
Matricellular proteins in cardiac adaptation and disease
NG Frangogiannis - Physiological reviews, 2012 - journals.physiology.org
The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …