The need for a quantitative and operator-independent assessment of coronary
microvascular function is increasingly recognized. We propose the theoretical framework of …

One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Functional vasculature is essential for delivering nutrients, oxygen, and cells to the heart and
removing waste products. Here, we developed an in vitro vascularized human cardiac …

Aims The microvascular resistance reserve (MRR) was introduced as a means to
characterize the vasodilator reserve capacity of the coronary microcirculation while …

Preclinical large animal models of heart failure (HF) play a critical and expanding role in
translating basic science findings to the development and clinical approval of novel …

Aim To explore the beneficial effects of L‐carnitine on cardiac microvascular dysfunction in
diabetic cardiomyopathy from the perspectives of mitophagy and mitochondrial integrity …

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …

In this study, we report static and perfused models of human myocardial-microvascular
interaction. In static culture, we observe distinct regulation of electrophysiology of human …

The endothelium plays a pivotal role in the regulation of vascular tone by synthesizing and
liberating endothelium-derived relaxing factors inclusive of vasodilator prostaglandins (eg …