The entorhinal cortex (EC) is the brain region that often exhibits the earliest histological
alterations in Alzheimer's disease (AD), including the formation of neurofibrillary tangles and …

Exposure to chronic adverse conditions, and the resultant activation of the neurobiological
response cascade, has been associated with an increased risk of early onset of age-related …

The clinical presentation and the pathological processes underlying Alzheimer's disease
(AD) can be very heterogeneous in severity, location, and composition including the amount …

A few protein kinases and phosphatases regulate tau protein phosphorylation and an
imbalance in their enzyme activity results in tau hyper-phosphorylation. Aberrant tau …

Alzheimer's disease (AD) is the major cause of dementia that is now threatening the lives of
billions of elderly people on the globe, and recent progress in the elucidation of the …

Microglial activation is a central player in the pathophysiology of Alzheimer's disease (AD).
The soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) can …

Background This study investigated plasma biomarkers for neuroinflammation associated
with Alzheimer's disease (AD) in subjects with preclinical AD compared to healthy elderly …

Summary Background The apolipoprotein E (APOE) ε4 allele, involved in fatty acid (FA)
metabolism, is a major genetic risk factor for Alzheimer's disease (AD). This study examined …

Abstract Dementia, particularly Alzheimer's Disease (AD), has links to modifiable risk factors,
particularly physical inactivity. However, cognitive benefits are generally attributed to aerobic …

Abstract Background The Alzheimer's disease (AD) risk gene ABCA7 has suggested
functions in lipid metabolism and the immune system. Rare premature termination codon …