Asymmetric organocatalysis: an enabling technology for medicinal chemistry
B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …
enormously to the field of organic synthesis since the early 2000s. As asymmetric …
[HTML][HTML] Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives
The protein kinases regulate cellular functions such as transcription, translation,
proliferation, growth and survival by the process of phosphorylation. Over activation of …
proliferation, growth and survival by the process of phosphorylation. Over activation of …
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer
Z Yang, Q Zhang, L Yu, J Zhu, Y Cao, X Gao - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Triple-negative breast cancer (TNBC) has a poorer
prognosis than other subtypes due to its strong invasion and higher risk of distant …
prognosis than other subtypes due to its strong invasion and higher risk of distant …
Clinical management of breast cancer heterogeneity
Traditionally, intertumour heterogeneity in breast cancer has been documented in terms of
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …
different histological subtypes, treatment sensitivity profiles, and clinical outcomes among …
[HTML][HTML] Perspectives on triple-negative breast cancer: current treatment strategies, unmet needs, and potential targets for future therapies
GK Gupta, AL Collier, D Lee, RA Hoefer, V Zheleva… - Cancers, 2020 - mdpi.com
Triple-negative breast cancer (TNBC), characterized by the absence or low expression of
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …
[HTML][HTML] TranSynergy: Mechanism-driven interpretable deep neural network for the synergistic prediction and pathway deconvolution of drug combinations
Q Liu, L Xie - PLoS computational biology, 2021 - journals.plos.org
Drug combinations have demonstrated great potential in cancer treatments. They alleviate
drug resistance and improve therapeutic efficacy. The fast-growing number of anti-cancer …
drug resistance and improve therapeutic efficacy. The fast-growing number of anti-cancer …
The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene …
M Samimi, MH Pourhanifeh… - Journal of cellular …, 2019 - Wiley Online Library
Endometriosis is a frequent and chronic illness in young women which could be defined by
the existence of endometrial stroma and glands outside of the normal site of the lining of the …
the existence of endometrial stroma and glands outside of the normal site of the lining of the …
Multispecific Platinum (IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1
S Jin, N Muhammad, Y Sun, Y Tan, H Yuan… - Angewandte …, 2020 - Wiley Online Library
Breast cancer (BC) is one of the most common malignancies in women and often
accompanied by inflammatory processes. Cyclooxygenase‐2 (COX‐2) plays a vital role in …
accompanied by inflammatory processes. Cyclooxygenase‐2 (COX‐2) plays a vital role in …
[HTML][HTML] Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma
S Yang, G Liu - Oncology letters, 2017 - spandidos-publications.com
Although the biological basis of hepatocellular carcinoma (HCC) remains unclear, effective
treatments and improvement of the survival rate remain worthwhile research goals …
treatments and improvement of the survival rate remain worthwhile research goals …