Chronic inflammation is a pathological condition characterized by continued active
inflammation response and tissue destruction. Many of the immune cells including …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

A wide array of chronic inflammatory conditions predispose susceptible cells to neoplastic
transformation. In general, the longer the inflammation persists, the higher the risk of cancer …

Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an
inflammatory/immunosuppressive injury response that promotes dormancy escape and …

Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …

Abstract Reactive Oxygen Species (ROS) result from cell metabolism as well as from
extracellular processes. ROS exert some functions necessary for cell homeostasis …

Cyclooxygenase (COX), a prostaglandin-endoperoxide synthase (PTGS), catalyzes the
formation of prostaglandins from arachidonic acid. Prostaglandins are lipid signaling …

A wide array of antioxidative and anti-inflammatory substances derived from edible plants
have been reported to possess chemopreventive and chemoprotective activities. Among the …

The essential fatty acids, linoleic acid and arachidonic acid play an important role in
pancreatic cancer development and progression. These fatty acids are metabolized to …

The expansion of myeloid-derived suppressor cells (MDSCs) is a common feature of cancer,
but its biological roles and molecular mechanism remain unclear. Here, we investigated a …