Hemoglobinopathies are the most common monogenic disorders in the world with an ever
increasing global disease burden each year. As most hemoglobinopathies show recessive …

Thalassemia syndromes are among the commonest monogenic disorders and represent a
substantial health burden worldwide. Here the authors have described globin genes …

Thalassemias are a group of inherited blood disorders that affects 5–7% of the world
population. Comprehensive screening strategies are essential for the management and …

Thalassaemia is a common hereditary haemolytic anaemia. Mild cases of this disease may
be asymptomatic, while patients with severe thalassaemias require high-dose blood …

Conventional methods for the diagnosis of thalassemia include gap polymerase chain
reaction (Gap-PCR), reverse membrane hybridization (RDB), multiplex ligation-dependent …

Background Thalassemia is a common inherited haemoglobin disorder worldwide, several
methods have been utilized in the step-wise screening. Even though hundreds of mutations …

Thalassemia is identified as a prevalent disease in Malaysia, known to be one of the
developing countries. Fourteen patients with confirmed cases of thalassemia were recruited …

Background Thalassemia is the most frequent recessive Mendelian inherited monogenic
disease worldwide, and is characterized by the impaired synthesis of globin chains due to …

Objectives To present a novel 91.5-kb deletion of the α-globin gene cluster (αα) FJ identified
by genetic assay and prenatal diagnosis in a Chinese family. Subjects and Methods The …

Thalassemia is one of the most prevalent monogenic disorders in low-and middle-income
countries (LMICs). There are an estimated 270 million carriers of hemoglobinopathies …