Atrial cardiomyopathy: pathophysiology and clinical consequences

A Goette, U Lendeckel - Cells, 2021 - mdpi.com
Around the world there are 33.5 million patients suffering from atrial fibrillation (AF) with an
annual increase of 5 million cases. Most AF patients have an established form of an atrial …

Reviewing atrial fibrillation pathophysiology from a network medicine perspective: the relevance of structural remodeling, inflammation, and the immune system

ILF Martins, FVS Almeida, KP Souza, FCF Brito… - Life, 2023 - mdpi.com
Atrial fibrillation (AF) is the most common type of sustained arrhythmia. The numerous gaps
concerning the knowledge of its mechanism make improving clinical management difficult …

Transcriptomic uniqueness and commonality of the ion channels and transporters in the four heart chambers

S Iacobas, B Amuzescu, DA Iacobas - Scientific reports, 2021 - nature.com
Myocardium transcriptomes of left and right atria and ventricles from four adult male C57Bl/6j
mice were profiled with Agilent microarrays to identify the differences responsible for the …

Cardioprotective role of heat shock proteins in atrial fibrillation: from mechanism of action to therapeutic and diagnostic target

SW van Wijk, KS Ramos, BJJM Brundel - International journal of …, 2021 - mdpi.com
Atrial fibrillation (AF) is the most common age-related cardiac arrhythmia worldwide and is
associated with ischemic stroke, heart failure, and substantial morbidity and mortality …

Atrial fibrillation: mechanism and clinical management

Z Hu, L Ding, Y Yao - Chinese Medical Journal, 2023 - mednexus.org
Atrial fibrillation (AF), the most common sustained arrhythmia, is associated with a range of
symptoms, including palpitations, cognitive impairment, systemic embolism, and increased …

Identification of genomic signatures in bone marrow associated with clinical response of CD19 CAR T-cell therapy

L Shao, A Iyer, Y Zhao, R Somerville, S Panch… - Scientific Reports, 2022 - nature.com
Abstract CD19 CAR T-cell immunotherapy is a breakthrough treatment for B cell
malignancies, but relapse and lack of response remain a challenge. The bone marrow …

Preprocessing of Public RNA-Sequencing Datasets to Facilitate Downstream Analyses of Human Diseases

N Rapier-Sharman, J Krapohl, EJ Beausoleil… - Data, 2021 - mdpi.com
Publicly available RNA-sequencing (RNA-seq) data are a rich resource for elucidating the
mechanisms of human disease; however, preprocessing these data requires considerable …

[HTML][HTML] Alterations in cytoskeletal and Ca2+ cycling regulators in atria lacking the obscurin Ig58/59 module

A Grogan, W Huang, A Brong, MA Kane… - Frontiers in …, 2023 - frontiersin.org
Obscurin (720-870 kDa) is a giant cytoskeletal and signaling protein that possesses both
structural and regulatory functions in striated muscles. Immunoglobulin domains 58/59 …

NBioinfo: Establishing a Bioinformatics Core in a University-based General Hospital in South Brazil

M Recamonde-Mendoza, GCV Silva… - Journal of Information …, 2024 - sol.sbc.org.br
Bioinformatics is an indispensable discipline for current research in life and medical
sciences. The increasing volume and complexity of biological data and the growing …

[HTML][HTML] Evaluation of cellular response to Clostridium difficile toxin-A: a network analysis

B Arjmand, SJ Sherafat, MR Tavirani… - … and Hepatology From …, 2022 - ncbi.nlm.nih.gov
Aim: The current study aimed to determine crucial genes targeted by toxin-A through
network analysis. Background: Clostridium difficile (C difficile) produces toxin-A and toxin-B …