Peptide–drug conjugates with different linkers for cancer therapy
M Alas, A Saghaeidehkordi, K Kaur - Journal of medicinal …, 2020 - ACS Publications
Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …
Cell penetrating peptides: A versatile vector for co-delivery of drug and genes in cancer
MM Khan, N Filipczak, VP Torchilin - Journal of controlled release, 2021 - Elsevier
Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
penetrating peptides (CPP) have the ability to rapidly internalize across biological …
Cell-penetrating peptides (CPPs): An overview of applications for improving the potential of nanotherapeutics
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …
continues to be an ultimate challenge. There are many physicochemical factors such as …
In situ activation of therapeutics through bioorthogonal catalysis
Bioorthogonal chemistry refers to any chemical reactions that can occur inside of living
systems without interfering with native biochemical processes, which has become a …
systems without interfering with native biochemical processes, which has become a …
[HTML][HTML] Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?
C Fu, L Yu, Y Miao, X Liu, Z Yu, M Wei - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide
We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs)
conjugated to a cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced …
conjugated to a cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced …
Status update in the use of cell-penetrating peptides for the delivery of macromolecular therapeutics
K Kurrikoff, B Vunk, Ü Langel - Expert Opinion on Biological …, 2021 - Taylor & Francis
Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …
[HTML][HTML] Combination of cell-penetrating peptides with nanomaterials for the potential therapeutics of central nervous system disorders: a review
Y Zhang, P Guo, Z Ma, P Lu, D Kebebe… - Journal of …, 2021 - Springer
Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …
we have witnessed the soared incidence of central nervous system (CNS) diseases …
RGD peptide‐drug conjugates as effective dual targeting platforms: recent advances
In recent years, targeted therapies have raised increasing interest as effective strategies to
improve therapeutic efficiency, reduce the impact of adverse side effects, and overcome …
improve therapeutic efficiency, reduce the impact of adverse side effects, and overcome …
Identification of a PH-Responsive Peptide–Paclitaxel Conjugate as a Novel Drug with Improved Therapeutic Potential
A highly sensitive, nontoxic, hydrophilic cell-penetrating peptide (CPP= c [RGDKLAK]) was
selected for the construction of an effective peptide–drug conjugate (PDC). A hydrophobic …
selected for the construction of an effective peptide–drug conjugate (PDC). A hydrophobic …