Drug conjugates are chemotherapeutic or cytotoxic agents covalently linked to targeting
ligands such as an antibody or a peptide via a linker. While antibody–drug conjugates …

Biological barriers hamper the efficient delivery of drugs and genes to targeted sites. Cell
penetrating peptides (CPP) have the ability to rapidly internalize across biological …

In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell
continues to be an ultimate challenge. There are many physicochemical factors such as …

Bioorthogonal chemistry refers to any chemical reactions that can occur inside of living
systems without interfering with native biochemical processes, which has become a …

Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs)
conjugated to a cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced …

Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …

Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

In recent years, targeted therapies have raised increasing interest as effective strategies to
improve therapeutic efficiency, reduce the impact of adverse side effects, and overcome …

A highly sensitive, nontoxic, hydrophilic cell-penetrating peptide (CPP= c [RGDKLAK]) was
selected for the construction of an effective peptide–drug conjugate (PDC). A hydrophobic …