We review drug addiction from the perspective of the hypothesis that drugs of abuse interact
with distinct brain memory systems. We focus on emotional and procedural forms of memory …

Background Our ability to measure the cognitive components of complex decision-making
across species has greatly facilitated our understanding of its neurobiological mechanisms …

Substance use disorders (SUDs) are a growing public health concern with only a limited
number of approved treatments. However, even approved treatments are subject to limited …

Studies using brain imaging methods have shown that neuronal activity in the orbitofrontal
cortex, a brain area thought to promote the ability to control behavior according to likely …

Cocaine addiction is characterized by poor judgment and maladaptive decision-making.
Here we review evidence implicating the orbitofrontal cortex in such behavior. This evidence …

Background The predominant view of chronic cocaine use maintains that it causes a broad
range of cognitive deficits. However, concerns about the possibly deleterious impact of …

Once thought to produce global, nonspecific brain injury, drugs of abuse are now known to
produce selective neuroadaptations in particular brain regions. These neuroadaptations are …

Although the pharmacology of amphetamine-like psychostimulants at dopamine transporters
is well understood, addiction to this class of drugs has proven difficult to deal with. The …

Drug addicts have deficits in frontocortical function and cognition even long after the
discontinuation of drug use. It is not clear, however, whether the cognitive deficits are a …

Evidence of stimulus attribute‐specificity within the prefrontal cortex (PFC) suggests that
different prefrontal subregions may contribute to cocaine addiction in functionally distinct …