Cathepsin D is a lysosomal acid proteinase which is involved in the malignant progression
of breast cancer and other gynecological tumors. Clinical investigations have shown that in …

Ligand-induced activation of G protein-coupled receptors is emerging as an important
pathway leading to the activation of certain receptors with intrinsic tyrosine kinase activity …

Estrogens have been widely implicated in the genesis and progression of breast cancer.
Over 200 years ago, the Italian physician Ramazzini observed an increased incidence of …

Cathepsins, which are secreted by tumour and/or stromal cells, are thought to be involved in
the degradative processes of tumour invasion and metastasis. The purpose of our study was …

Matrix metalloproteinase-2 (MMP-2) and cathepsin D (CD) play a significant role in
degrading the components of basement membrane and extracellular matrix (ECM), whereas …

Down-regulation of receptors involved in the recognition or transmission of inflammatory
signals and a reduced responsiveness support the concept that macrophages are …

Despite recent advances in surgical techniques and therapeutic treatments, survival from
colorectal cancer (CRC) remains disappointing with some 40–50% of newly diagnosed …

Crohn's Disease and Ulcerative Colitis Are Associated With t... : Annals of Surgery Crohn's
Disease and Ulcerative Colitis Are Associated With the DNA Repair Gene MLH1 : Annals of …

Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the
advantages and limitations of the use of proteinases and their inhibitors in human pathology …

Objective. Colorectal cancer is a major cause of cancer mortality in the industrialized nations
in the West. Because mortality is closely related to the stage of the disease at the time of …