The molecular basis and disease relevance of non-homologous DNA end joining
B Zhao, E Rothenberg, DA Ramsden… - … Reviews Molecular Cell …, 2020 - nature.com
Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
The emerging and uncultivated potential of CRISPR technology in plant science
The application of clustered regularly interspaced short palindromic repeats (CRISPR) for
genetic manipulation has revolutionized life science over the past few years. CRISPR was …
genetic manipulation has revolutionized life science over the past few years. CRISPR was …
Non-homologous DNA end joining and alternative pathways to double-strand break repair
HHY Chang, NR Pannunzio, N Adachi… - … reviews Molecular cell …, 2017 - nature.com
DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …
Nonhomologous DNA end-joining for repair of DNA double-strand breaks
NR Pannunzio, G Watanabe, MR Lieber - Journal of Biological Chemistry, 2018 - ASBMB
Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …
DNA damage: from threat to treatment
A Carusillo, C Mussolino - Cells, 2020 - mdpi.com
DNA is the source of genetic information, and preserving its integrity is essential in order to
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
sustain life. The genome is continuously threatened by different types of DNA lesions, such …
Structural basis of long-range to short-range synaptic transition in NHEJ
DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …
Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair
Non-homologous end-joining (NHEJ) plays an important role in double-strand break (DSB)
repair of DNA. Recent studies have shown that the error patterns of NHEJ are strongly …
repair of DNA. Recent studies have shown that the error patterns of NHEJ are strongly …
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Engineered SpCas9s and AsCas12a cleave fewer off-target genomic sites than natural
SpCas9. However, understanding their fidelity, mechanisms and cleavage outcomes …
SpCas9. However, understanding their fidelity, mechanisms and cleavage outcomes …
The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis
One of the most central questions about the repair of a double-strand DNA break (DSB)
concerns how the two free DNA ends are brought together—a step called synapsis. Using …
concerns how the two free DNA ends are brought together—a step called synapsis. Using …
Extinction of all infectious HIV in cell culture by the CRISPR-Cas12a system with only a single crRNA
Z Gao, M Fan, AT Das, E Herrera-Carrillo… - Nucleic Acids …, 2020 - academic.oup.com
The CRISPR-Cas9 system has been used for genome editing of various organisms. We
reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a …
reported inhibition of the human immunodeficiency virus (HIV) in cell culture infections with a …